Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during

autophagy pathway p62  Attenuation of cGAS-STING signaling is mediated by a p62SQSTM1-dependent autophagy pathway activated by TBK1 -article  Interestingly, our laboratory's long-time interest SQSTM1p62 has also been shown to be critical for aggregation of misfolded proteins and their autophagic

We show that the ubiquitin-binding adaptor proteins p62 and NDP52 target Shigella to an autophagy pathway dependent upon septin and actin In contrast, p62 or A noncanonical autophagy pathway restricts toxoplasma gondii growth in a strain-specific manner in IFN-γ-activated human cells mBio 2015;6

However, the exact recognition mode of degrading substrates and regulation of p62 in the autophagic pathway remain unknown Here, we present the complex p62 was well known to act as a scaffold protein in signaling pathways involving NF-κB , but to also accumulate in ubiquitin